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KMID : 1123920060200020455
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 2 p.455 ~ p.459
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Evaluation of Korean Phytomedicinal Plants on inhibition of Prostaglandin Production and Cyclooxygenase-2 (COX-2) in LPS-stimulated U937 Cells
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Jang Seon-Il
Jun Chang-Soo
Kwak Kyung-Chell
Bae Moon-Sung
Lee Jung-Ho
Kim Ki-Young
Yun Young-Gab
Chai Gyu-Yun
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Abstract
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The inhibitors of prostaglandin production and cyclooxygenase-2 (COX-2) activity have been considered as potential anti-inflammatory agents. In this study, we evaluated 9 compounds isolated from 5 Korean phytomedicinal plants (Spirea prunifolia, Paeonia suffruticosa, Salvia miltiorrhiza, Scutellaria baicalensis, and Artemisia capillaris) for the inhibition of production and COX-2 expession in lipopolysaccharide (LPS)-stimulated human macrophages U937 cells. As a result, several compound such as prunioside A, penta-O-galloyl-beta-D-glucose, tanshinone IIA, baicalin, baicalein, wogonin, scopolatin, scoparone and decursinol showed potent inhibition of production (50-70% inhibition at the test concentration of ). In addition, these compounds were also considered as potential inhibitors of COX-2 activity (45-73% inhibition at the test concentration of ). These active compound mediating COX-2 inhibitory activities are warranted for further elucidation of active principles for development of anti-inflammatory agents and these properties may contribute to the anti-atopic dermatitis activity.
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KEYWORD
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cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), U937 cells, phytomedicinal plants, anti-inflammatory agents
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